| Home – Away | Score | FT | UO | ||
|---|---|---|---|---|---|
 | KV Mechelen vs St. Truiden 23 Sep – 21:00 EAT – Belgium – Jupiler League | 2-0 | 1 | O | |
 | Manisaspor vs Istanbulspor AS 23 Sep – 21:00 EAT – Turkey – TFF 1. Lig | 1-2 | 1 | U | |
 | Den Haag vs Sparta Rotterdam 23 Sep – 21:45 EAT – Netherlands – Eredivisie | 1-0 | 1 | O | |
 | DC United vs San Jose Earthquakes 24 Sep – 02:00 EAT – USA – MLS | 4-0 | 1 | O | |
| Philadelphia Union vs Chicago Fire 24 Sep – 02:00 EAT – USA – MLS | 3-1 | 1 | O | |
 | Dep. Capiata vs Sol de America 24 Sep – 03:10 EAT – Paraguay – Primera Division | 3-0 | X | U | |
| Real Salt Lake vs Seattle Sounders 24 Sep – 04:30 EAT – USA – MLS | 2-0 | 1 | O |