| Home – Away | Score | FT | UO | ||
|---|---|---|---|---|---|
 | Portimonense vs Feirense 18 Sep – 21:00 EAT – Portugal – Primeira Liga | 2-1 | 1 | O | |
 | Avellino vs Venezia 18 Sep – 21:30 EAT – Italy – Serie B | 1-1 | 1 | O | |
 | Espanyol vs Celta Vigo 18 Sep – 22:00 EAT – Spain – LaLiga | 2-1 | X | U | |
 | Sud America vs Juventud 18 Sep – 22:00 EAT – Uruguay – Primera Division | 1-1 | 1 | O | |
| Chaves vs Moreirense 18 Sep – 23:00 EAT – Portugal – Primeira Liga | 3-0 | 1 | O | |
 | Tombense vs CSA 19 Sep – 02:45 EAT – Brazil – Serie C | 0-2 | 1 | U | |
 | Bucaramanga vs Ind. Medellin 19 Sep – 04:00 EAT – Colombia – Liga Aguila | 1-1 | 2 | U |