| C | Time | Home – Away | Score | FT | UO | |
|---|---|---|---|---|---|---|
 | 21:00 EAT | Celta Vigo vs Shakhtar Donetsk | 0-1 | X | U | |
| 21:00 EAT | Ludogorets vs FC Copenhagen | 1-2 | 1 | U | |
| 21:00 EAT | B. Monchengladbach vs Fiorentina | 0-1 | 1 | O | |
| 23:05 EAT | H. Beer Sheva vs Besiktas | 1-3 | 2 | U | |
| 23:05 EAT | Legia vs Ajax | 0-0 | X | U | |
| 23:05 EAT | Anderlecht vs Zenit Petersburg | 2-0 | 1 | O | |
| 23:05 EAT | Villarreal vs AS Roma | 0-4 | X | U |