| Home – Away | Score | FT | UO | ||
|---|---|---|---|---|---|
 | Antwerp vs Waregem 15 Oct – 21:00 EAT – Belgium – Jupiler League | 3-0 | 2 | U | |
 | Betis vs Valencia 15 Oct – 21:45 EAT – Spain – LaLiga | 3-6 | 2 | O | |
 | Inter vs AC Milan 15 Oct – 21:45 EAT – Italy – Serie A | 3-2 | 1 | O | |
 | Sport Recife vs Atletico-MG 15 Oct – 22:00 EAT – Brazil – Serie A | 1-1 | 1 | O | |
 | Bogota vs Quindio 15 Oct – 22:00 EAT – Colombia – Torneo Aguila | 0-2 | 2 | O | |
 | Guadalupe vs Santos DG 15 Oct – 22:00 EAT – Costa Rica – Primera Division | 0-4 | 2 | O | |
| Llaneros vs Orsomarso 15 Oct – 23:30 EAT – Colombia – Torneo Aguila | 1-2 | 1 | O |