| C | Time | Home – Away | Score | FT | UO | |
|---|---|---|---|---|---|---|
 | 20:45 EAT | Excelsior vs Vitesse | 1-0 | 2 | O | |
 | 21:00 EAT | Guingamp vs Toulouse | 2-1 | 1 | O | |
| 21:00 EAT | Metz vs Caen | 2-2 | X | U | |
 | 21:00 EAT | KSV Roeselare vs Mouscron | 3-5 | X | U | |
 | 21:30 EAT | Orlando City vs Los Angeles Galaxy | 2-1 | X | U | |
 | 23:00 EAT | San Felipe vs San Marcos de Arica | 2-0 | 2 | U | |
 | 23:30 EAT | U. San Martin vs AD Cantolao | 1-2 | 1 | O |