| C | Time | Home – Away | Score | FT | UO | |
|---|---|---|---|---|---|---|
 | 02:00 EAT | Capivariano SP vs Velo Clube SP | 2-1 | 2 | U | |
 | 03:00 EAT | U. Catolica vs San Lorenzo | 1-1 | 1 | O | |
 | 03:00 EAT | Queretaro vs Club Tijuana | 0-1 | X | U | |
| 03:30 EAT | Santos Laguna vs Monterrey | 2-2 | 2 | O | |
 | 05:00 EAT | San Carlos vs Alajuelense | 0-1 | 2 | O | |
| 05:00 EAT | U.C.R. vs Liberia | 1-1 | 2 | O | |
| 05:30 EAT | Atlas vs U.N.A.M.- Pumas | 1-1 | 1 | U |