| C | Time | Home – Away | Score | FT | UO | |
|---|---|---|---|---|---|---|
 | 21:00 EAT | APOEL vs Anderlecht | 0-1 | 2 | U | |
| 21:00 EAT | FC Copenhagen vs Ajax | 2-1 | X | U | |
| 23:05 EAT | Schalke vs B. Monchengladbach | 1-1 | 1 | O | |
| 23:05 EAT | Gent vs Genk | 2-5 | 1 | U | |
| 23:05 EAT | Olympiakos Piraeus vs Besiktas | 1-1 | 2 | U | |
| 23:05 EAT | Lyon vs AS Roma | 4-2 | 1 | O | |
 | 23:30 EAT | Comerciantes Unidos vs U. de Deportes | 3-0 | X | U |