| C | Time | Home – Away | Score | FT | UO | |
|---|---|---|---|---|---|---|
 | 20:00 EAT | Palermo vs Crotone | 1-0 | X | U | |
 | 20:00 EAT | Waregem vs Gent | 1-1 | 2 | U | |
 | 21:00 EAT | U.N.A.M.- Pumas vs Pachuca | 1-1 | 1 | U | |
| 22:00 EAT | Westerlo vs St. Truiden | 1-0 | 2 | O | |
 | 22:00 EAT | Girona vs Valladolid | 2-1 | 1 | U | |
 | 23:00 EAT | St Etienne vs Lyon | 2-0 | 2 | O | |
 | 00:00 EAT | Plaza Colonia CD vs CA Boston River | 0-0 | – | – |