| C | Time | Home – Away | Score | FT | UO | |
|---|---|---|---|---|---|---|
 | 21:00 EAT | 1. FSV Mainz 05 vs RB Leipzig | 2-3 | 2 | O | |
 | 21:30 EAT | Gijon vs Malaga | 0-1 | 1 | O | |
 | 21:45 EAT | Huddersfield vs Norwich | 3-0 | 1 | U | |
 | 21:45 EAT | Napoli vs Juventus | 3-2 | 2 | O | |
 | 21:45 EAT | St Johnstone vs Hearts | 1-0 | 2 | O | |
| 21:45 EAT | Motherwell vs Hamilton | 0-0 | 1 | O | |
| 22:00 EAT | Chelsea vs Manchester City | 2-1 | 1 | O |