| Home – Away | Score | Picks | ||
|---|---|---|---|---|
 | Stoke City vs Bournemouth 21 Oct – 17:00 EAT – England – Premier League | 1-2 | 1X | |
| Swansea vs Leicester 21 Oct – 17:00 EAT – England – Premier League | 1-2 | X2 | |
 | Feirense vs Rio Ave 21 Oct – 18:00 EAT – Portugal – Primeira Liga | 1-0 | 2 | |
 | Valencia vs Sevilla 21 Oct – 19:30 EAT – Spain – LaLiga | 4-0 | 1 | |
| Setubal vs Maritimo 21 Oct – 20:15 EAT – Portugal – Primeira Liga | 3-1 | X2 | |
 | Metz vs Dijon 21 Oct – 21:00 EAT – France – Ligue 1 | 1-2 | 2 | |
| Nantes vs Guingamp 21 Oct – 21:00 EAT – France – Ligue 1 | 2-1 | 1 | |
| Rennes vs Lille 21 Oct – 21:00 EAT – France – Ligue 1 | 1-0 | 1 | |
 | FC Koln vs SV Werder Bremen 22 Oct – 14:30 EAT – Germany – Bundesliga | 0-0 | 1 | |
 | Spal vs Sassuolo 22 Oct – 16:00 EAT – Italy – Serie A | 0-1 | 2 | |
| SC Freiburg vs Hertha Berlin 22 Oct – 16:30 EAT – Germany – Bundesliga | 1-1 | 1X | |
| Tottenham vs Liverpool 22 Oct – 18:00 EAT – England – Premier League | 4-1 | X2 | |
| Tondela vs Belenenses 22 Oct – 18:00 EAT – Portugal – Primeira Liga | 2-0 | 2 | |
| Wolfsburg vs Hoffenheim 22 Oct – 19:00 EAT – Germany – Bundesliga | 1-1 | 1 | |
| Leganes vs Ath Bilbao 22 Oct – 19:30 EAT – Spain – LaLiga | 1-0 | 2 |